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We set out to create a new therapeutic delivery mechanism that would have a high utilization and benefit by making it a tasty and enjoyable treat - an avant-garde, long-lasting, treat that increases the pH and optimizes the oral conditions needed for remineralization while providing all the benefits of increased alkaline consumption. A candy that neutralizes the acids and provides ample BIOAVAILABLE building blocks (calcium, phosphate and *fluoride ions) that can foster healthy teeth by helping prevent further demineralization, decreasing plaque and potentially helping heal non-cavitated carious lesions (*8 pg 77,*12,*16,*18). It also provides for increased contact time-which is critical for active uptake of the above ions.

In addition to remineralization of carious lesions, the candy also helps oral health by decreasing the bio-burden and changing the oral pH (10, *11). The candy contains encapsulated β-TCP (*18,*25,*26) which imparts a texture to the surface of the candy. As the tongue runs over it, it dissolved the encapsulation and releasing bioavailable Calcium and Phosphate while also getting cleansed the tongue as an additional benefit; thus providing a mechanical way to reduce the total oral bacterial count, improve tongue hygiene and decrease halitosis (*23, *24). Can also be a very healthy medication deliver method.

The rather than Xylitol, DREAM candy uses erythritol (*13, *14, *16) since it is non-caloric, non-cariogenic and reduces the reproduction of oral bacteria. It showed superior results in lower concentrations (*14) and has a glycemic index of 0 when compared to xylitol’s glycemic index of 13. Additionally, only 10% of erythritol is metabolized as opposed to 50% of xylitol which can lead to reduced gastric issues (*13, *21).

DREAM Candy is especially beneficial for those with decreased saliva since it has the buffering ability and bio available Calcium and Phosphate that normal saliva contains delivered in a more concentrated and portable package.

The Science to Date on the Solution:

Testing done by Dr John Burgess to measure the pH of and look at the impact of the various candies on tooth structure. He cycled the teeth between Lactic Acid and Candy solutions for 3 minutes each for 1000 times– Mimicking the worst oral environment; he results were astounding (*15). This is due to DREAM candy’s ability to provide a constant release of bio-available ions in a non-acidic pH environment needed for remineralization over an extended time (*1, *15)-  which provides for a protective and reparative capacity (*1, *8,*16).

The following images demonstrate findings after cycling teeth between lactic acid and candy solutions 1000x. Note that the dramatic difference in cavitation under these extreme conditions

*Trace amounts of fluoride and other minerals may be found in the water supply used to produce Dr. John's Healthy Sweets.  

REFERENCES:  (link to the study>Title of the study>Summary)

 *1. Demineralization–remineralization dynamics in teeth and bone - Biomineralization is a dynamic, complex, lifelong process by which living organ­isms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization–remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.

*2. The effect of xylitol on dental caries and oral flora - Dental caries, the most chronic disease affecting mankind, has been in the limelight with regard to its prevention and treatment. Professional clinical management of caries has been very successful in cases of different severities of disease manifestations. However, tertiary management of this disease has been gaining attention, with numerous methods and agents emerging on a daily basis. Higher intake of nutritive sweeteners can result in higher energy intake and lower diet quality and thereby predispose an individual to conditions like obesity, cardiovascular disorders, and type 2 diabetes mellitus. Non-nutritive sweeteners have gained popularity as they are sweeter and are required in substantially lesser quantities. Xylitol, a five-carbon sugar polyol, has been found to be promising in reducing dental caries disease and also reversing the process of early caries. This paper throws light on the role and effects of various forms of xylitol on dental caries and oral hygiene status of an individual

*3.   Effectiveness of Xylitol in Reducing Dental Caries in Children:  Effectiveness of Xylitol in Reducing Dental Caries in Children - Based on this study’s results, the following conclusions can be made: (1) The present systematic review examining the effective-ness of xylitol on caries incidence in children, showed a small effect size in randomized controlled trials and a very low quality of evidence that makes preventive action of xylitol uncertain. And (2) The effect size of xylitol was greater with higher xylitol doses (greater than four grams per day).

*4. Saliva and dental erosion - Dental erosion is a multifactorial condition. The consideration of chemical, biological and behavioral factors is fundamental for its prevention and therapy. Among the biological factors, saliva is one of the most important parameters in the protection against erosive wear.

*5. The pH of beverages in the United States - Most (93%, 354 of 379) beverages had a pH of less than 4.0, and 7% (25 of 379) had a pH of 4.0 or more. Relative beverage erosivity zones based on studies of apatite solubility in acid indicated that 39% (149 of 379) of the beverages tested in this study were considered extremely erosive (pH < 3.0), 54% (205 of 379) were considered erosive (pH 3.0 to 3.99), and 7% (25 of 379) were considered minimally erosive (pH ≥ 4.0).

*6. Recent Trends – Per Capita Soft Drink Consumption - Soda consumption is estimated at 42.9 gallons per person. This does not include Sports drinks and carbonated waters, etc.

*7. Sour sweets: a new type of erosive challenge? - The pH of the sour sweets ranged from 2.30-3.14 with their neutralisable acidity ranging from 9.78-66.9 ml of 0.1M NaOH. The amount of permanent enamel removed following one hour immersion in the drinks ranged from 2.16-10.88 microm and from 1.02-18.34 microm for deciduous enamel. In comparison, the orange juice (Tropicana smooth) control had a pH of 3.86, a neutralisable acidity of 37.1 ml of 0.1M NaOH and removed 5.23 microm of permanent enamel and 6.27 microm of deciduous enamel. All the sour sweets tested were found to be erosive, some more so than orange juice.

*8. (2006) & (2014): Understanding the chemistry of dental erosion - The mineral in our teeth is composed of a calcium-deficient carbonated hydroxyapatite containing impurity ions such as Na(+), Mg(2+) and Cl(-). These substitutions in the mineral crystal lattice, especially carbonate, renders tooth mineral more acid soluble than hydroxyapatite. During erosion by acid and/or chelators, these agents interact with the surface of the mineral crystals, but only after they diffuse through the plaque, the pellicle, and the protein/lipid coating of the individual crystals themselves. The effect of direct attack by the hydrogen ion is to combine with the carbonate and/or phosphate releasing all of the ions from that region of the crystal surface leading to direct surface etching. Acids such as citric acid have a more complex interaction. In water they exist as a mixture of hydrogen ions, acid anions (e.g. citrate) and undissociated acid molecules, with the amounts of each determined by the acid dissociation constant (pKa) and the pH of the solution. Above the effect of the hydrogen ion, the citrate ion can complex with calcium also removing it from the crystal surface and/or from saliva. Values of the strength of acid (pKa) and for the anion-calcium interaction and the mechanisms of interaction with the tooth mineral on the surface and underneath are described in detail. The net effect of the solution factors determines the overall erosive potential of different products. Prospects for remineralization of erosive lesions are evaluated.

*9. Sports drinks and dental erosion- Sports drinks were originally developed to improve hydration and performance in athletes taking part in intense or endurance sporting events. These drinks contain relatively high amounts of carbohydrates (sugars), salt, and citric acid. These ingredients create the potential for dental ramifications and overall public health consequences such as obesity and diabetes. High intake of sports drinks during exercise, coupled with xerostomia from dehydration, may lead to the possibility of erosive damage to teeth.

*10. Saliva pH and Flow Rate in Patients with Periodontal Disease and Associated Cardiovascular Disease - Study suggests that the decrease of salivary flow rate and pH level might be associated with the severity of periodontal disease. A severe form of periodontal disease was found in 22.4% of patients. Disease severity was strongly correlated with low pH values (6.25 in stage IV periodontal disease), lower salivary flow rate (0.28 mL/min), smoking, poor oral hygiene habits and obesity, with no significant differences by sex. We observed a significant increase of pH (up to 6.30±0.17) in patients with severe periodontal disease (P=0.001) and salivary flow rate values (0.29±0.07 mL/min; P=0.014) 3 months after oral hygienization. There was a strong association between the severity of periodontal disease and presence of cardiovascular disease (P=0.001).

*11. Salivary pH: A diagnostic biomarker - The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001) whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001). These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker

*12. Remineralization of natural and artificial lesions in human dental enamel in vitro. Effect of calcium concentration of the calcifying fluid - Exposure of both small carious lesions and artificial caries-like lesions to a synthetic calcifying fluid in vitro produced a significant degree of ‘healing’ or remineralization of the lesion. Changing the calcium concentration of the calcifying fluid had a marked effect on the degree of remineralization produced.

*13. Erythritol as sweetener—wherefrom and whereto? – Erythritol is polyol that is non-caloric and majority of it cannot be metabolized by the human body and is excreted unmodified into the urine without changing blood glucose and insulin levels; thus a great choice for diabetics or people suffering obesity. It also means that a severe disadvantage of other polyols, namely sorbitol and xylitol, leading to diarrhea is eliminated. Only a little amount, less than 10%, undergoes a reversible metabolic reaction. Finally, erythritol is also a free radical scavenger with the ability to potentially exercise its anti-oxidant activity while circulating the body before it is excreted into the urine.

*14. Erythritol Is More Effective than Xylitol and Sorbitol in Managing Oral Health Endpoint – The review reported the important differences in the effect of individual polyols on oral health. The review provided evidence demonstrating better efficacy of erythritol compared to sorbitol and xylitol to maintain and improve oral health.

*15. Dr John Burgess Study on DREAM CandyArtificial Caries Study on Caries-Inhibition Effects of Experimental Candies - Experimental candy materials have significant effect to reduce demineralization, and therefore have potential caries-inhibition effect.

*16. Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries - Study found both xylitol and erythritol to express high growth inhibition effect on cariogenic bacteria. In synergistic effect experiments, 10% polyol combination with excess of erythritol was found to be more effective against growth of Streptococcus mutans and the combination with excess of xylitol more effective against growth of Streptococcus sobrinus and S. wiggsiae. In biofilm inhibition experiments, solutions of 10% polyols in different combinations and 15% single polyols were equally effective against mutans streptococci. At the same time, higher biofilm formation of S. wiggsiae compared to experiments without polyols was detected in different polyol concentrations for up to 34%. In conclusion, both erythritol and xylitol as well as their combinations inhibit the growth of different cariogenic bacteria. Biofilm formation of mutans streptococci is also strongly inhibited.

*17. Scaramucci T, Carvalho JC, Hara AT, Zero DT. Causes of Dental Erosion: Extrinsic Factors. Berlin: Springer International Publishing; 2015:69–96.

*18. Fluoride plus functionalized β-TCP: a promising combination for robust remineralization - Laboratory and clinical studies have demonstrated that the combination of fluoride and functionalized β-tricalcium phosphate (fTCP) produces stronger, more acid-resistant mineral relative to fluoride, native β-TCP, or fTCP alone.

*19. Per-capita consumption of energy & sports drinks in the U.S. 2015-2027 - The average consumption per capita in the energy & sports drinks segment of the non-alcoholic drinks market in the United States was forecast to continuously increase between 2023 and 2027 by in total 1.2 liters (+4.07 percent). The per-capita consumption is estimated to amount to 30.72 liters in 2027.

*20. Citric Acid - Citric acid is an excellent chelating agent, binding ions and making them soluble.

*21. : Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various plaque and salivary caries-related variables - Three-year consumption of erythritol-containing candies by initially 7- to 8-year old children was associated with reduced plaque growth, lower levels of plaque acetic acid and propionic acid, and reduced oral counts of mutans streptococci compared with the consumption of xylitol or sorbitol candies.

*22. Cariogenicity depends more on diet than the prevailing mutans streptococcal species – The review concluded that the cariogenicity of the diet determines the development of dental caries while hardly affecting the mutans streptococci counts explains the limited value of the latter as an indicator of dental caries.

*23. - Halitosis - Halitosis is a widespread condition presenting several social and psychological implications, leading to a reduction in the quality of life of an individual. Halitosis, per definition, defines an unpleasant smell of the exhaled air, independent of its etiology. It can have a long-term prevalence or be transient, making it difficult to establish this symptom's epidemiology. Oral malodor can be attributed to a high local concentration of intraoral microbial populations, particularly those of the tongue's biofilm, as well as the biofilms associated with teeth and periodontal tissue. Frequently, the treatment options rely on improving oral health via tongue cleaning, detecting periodontal diseases, insufficient dental restorations, alternating diets, and/or alleviating local factors. Different methods targeting specific bacteria species have been designed to improve this condition. The aim here is to underline the correlation between oral biofilms and halitosis, describing prime bacteria species influencing oral malodor and addressing new concepts to ameliorate this condition.

*24. Prevalence of periodontopathic bacteria on the tongue dorsum of elderly people - A wide range of species, including anaerobes, was detected in 85-year-old subjects. It was found that the detection of periodontal bacteria on the tongue coating increased with the number of teeth. There was a positive relationship between the tooth number and periodontopathic bacteria, except for A. actinomycetemcomitans. These results suggest that tongue care is essential for preventing oral disease and needs to be part of any oral care programme in elderly people.

*25. Effectiveness-of Calcium Phosphate derivative agents on the prevention and remineralization of caries among children- A systematic review & meta-analysis of randomized controlled trials - Topical treatment using CaP+F group showed superior remineralization potential as well as the antibacterial effect on dental caries among children as compared to no intervention and/or placebo or F alone. Apart from CPP-ACP, other CaP derivatives like TCP and fTCP seem to have promising effects in remineralizing early lesions, however, very few trials exist on these potential agents.

*26. The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries - All toothpastes in this study had the potential to delay the demineralization progression of artificial enamel caries in primary teeth. The fluoride 500 ppm and TCP toothpastes were equal in the deceleration of enamel caries progression and better than CPP-ACP paste and TCP toothpaste.